This week marks the European Launch of the new CE marked Human Complement C2 Kit to aid in the diagnosis of complement C2 deficiency.

The SPAPLUS Complement C2 Kit is intended for the quantitative in vitro measurement of human Complement C2 in EDTA plasma and serum using the SPAPLUS analyser.

C2 is a β1-glycoprotein which forms part of the classical complement pathway. It is cleaved by activated C1s into two fragments, C2a and C2b. The larger fragment of C2 then combines with C4b to produce C3 or C5 convertase. Reduced C2 plasma concentrations result from classical complement pathway activation, i.e. from immune complex mediated activation. C2 deficiency is the most common inherited complement component deficiency, and is associated with systemic lupus erythematosus, glomerulonephritis and vasculitis.

Commenting on the launch, International Product Manager Haydn Little, said “We are excited to launch the first fully automated Complement C2 assay for use on a turbidimetric analyser. This assay will further expand the menu of tests available on the SPAPLUS to aid clinicians in the diagnosis of complement deficiency.”

For more information or to order this assay please contact your local Binding Site office or distributor.

Complement C2 is part of a comprehensive assay menu specifically designed for the SPA_PLUS which is our optimised protein system. The menu consists of our flagship product Freelite^®, Subclasses as well as renal function and specific proteins. Each assay has been specifically designed for use on the SPA_PLUS to ensure optimal performance and confidence in results. Click here to view the SPA_PLUS assay menu.