The measurement of IgG subclasses can aid in the diagnosis of many immunodeficiency disorders including IgG subclass deficiency, IgA with IgG subclass deficiency, common variable immunodeficiency and specific antibody deficiency.
Patients with recurrent infections may still present with normal or elevated IgG levels making diagnosis of immune deficiency difficult. In these circumstances IgG subclass measurements may be a useful tool for diagnosis of primary immunodeficiency alongside other tests. There is often a delayed diagnosis of these patients resulting in a reduction of quality of life.
IgG4-Related Disease
IgG4-related disease (IgG4-RD) is a rare, immune-mediated and chronic fibro-inflammatory condition that can affect multiple organs. Quantification of serum IgG4 concentration is included in all IgG4-RD diagnostic guidelines to-date. 1, 2
Measuring IgG4 levels in serum can aid a timely diagnosis.
Binding Site provides an automated solution for the measurement of IgG Subclasses on the Optilite® analyser.
References
1.) Umehara, H., et al., Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol, 2012. 22(1): p. 21-30.
2.) Wallace, Z.S., et al., The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol, 2020. 72(1): p. 7-19.
