The complement system is a complex series of proteins that act as a cascade. They react in the sequence C1q, C1r, C1s, C4, C2, C3, C5, C6, C7, C8, C9; many requiring proteolytic cleavage to become active. The cascade is activated either via the Classical Pathway, the Lectin Pathway or the Alternative Pathway. Complement proteins are assayed to measure complement consumption and to diagnose inherited deficiencies of the individual cascade components.
Human Complement Functional Assays
Complement functional assays are used as screening tools to detect complement deficiencies and to aid in the monitoring of total complement activity.
The measurement of CH50 is recommended as part of the diagnostic protocol for Primary Immunodeficiency and it can also provide important information for many other disease states such as systemic lupus erythematosus and bacterial infections.
Human Complement Proteins
Where a complement deficiency is suspected it may be necessary to test for the specific components of the complement system.
Measurement of Complement Deficiencies
Complement is involved in initiating an inflammatory response and destroying certain bacteria and viruses. Complement proteins are assayed to measure complement consumption and to diagnose inherited deficiencies of cascade components.
