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Immunoglobulins

The measurement of immunoglobulin and immunoglobulin subclasses are key tools for the diagnosis of immune system disorders

IgG, A and M

The quantification of serum immunoglobulins is a vital first-line test in the investigation of primary immunodeficiency（PID）. These diagnostic assays test for the presence of agammaglobulinemia

and hypogammaglobulinemia.1,2 The results are often the basis for further investigative testing such as IgG Subclass testing and antibody function. Over half of individuals diagnosed with primary immunodeficiencies have defects in immunoglobulin levels.3

IgE

Measurement of total IgE can be useful to aid in the diagnosis of various diseases. Elevated IgE levels can be found in allergic disorders, atopy, Hyper IgE Syndromes (HIES), immune deficiencies, liver diseases, malignancies, parasitic infections, graft-versus host disease, severe burns and some viral infections.4

References
  1. de Vries, Clin Exp Immunol 2012;167:108-119
  2. Bonilla FA, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2015; 136:1186-1205
  3. Mahlaoui N, et al. The European Society for Immunodeficiencies (ESID) Registry: recent advancements in the epidemiology of Primary
  4. Marshall, W.J, Lapsley, M, Day, A. & Aylin, R.M. (2014) Clinical Biochemistry Metabolic and Clinical Aspects. Elsevier