Freelite in Guidelines

Serum free light chain assays are included in a range of International and National guidelines* including:

• International Myeloma Working Group
• The National Comprehensive Cancer Network
• European Society of Medical Oncology
• International Kidney and Monoclonal Gammopathy Research Group
• China Guidelines for the Diagnosis and Treatment of Multiple Myeloma (Revised 2017)

*All data used in these guidelines was generated using the Freelite^® free light chain assay.
It cannot be assumed that other commercially available free light chain assays will give compliance with these guidelines

International Myeloma Working Group and Local Guidelines

 International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
Rajkumar SV, et al. Lancet Oncology 2014; 15:e538-e548

International Myeloma Working Group recommendations for global myeloma care.
Ludwig H, et al. Leukemia 2014; 28:981-992

New Criteria for Response to Treatment in Immunoglobulin Light Chain Amyloidosis Based on Free Light Chain Measurement and Cardiac Biomarkers: Impact on Survival Outcomes.
Palladini, et al. J Clin Onc 2012; 30:4541-4549

Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1.
Rajkumar SV, et al, Blood 2011; 117:4691-4695

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, et al. Leukemia 2010; 24:1121-1127

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders.
Dispenzieri A, et al. Leukemia 2009; 23:215-224

International uniform response criteria for multiple myeloma.
Durie BGM, et al. Leukemia 2006; 20:1467-1473

Guidelines for Diagnosis and Treatment of Multiple Myeloma in China (2017 revision)
Chinese Medical Doctor Association hematology branch, Chinese medical association hematology branch, Chinese Medical Doctor Association multiple myeloma committee. Chinese Journal of Internal Medicine, November 2017, vol. 56, no. 11

Guidelines for the diagnosis and treatment of systemic light chain amyloidosis
Chinese systemic amyloidosis collaborating group, national kidney disease clinical research center. Chinese Journal of Medicine, vol. 96, no. 44, November 29, 2016