What Freelite results tell you

What Freelite Results tell you

The Freelite assay measures kappa and lambda immunoglobulin free light chains (FLCs) in mg/L.

These values can be expressed in different ways to assess a patient with a monoclonal gammopathy:

Term	Definition	Description	Example in a Lambda LCMM patient
FLC	Free Light Chain
iFLC	Involved FLC	The FLC type produced by the tumour	λ
uFLC	Uninvolved FLC	The alternate light chain type to the iFLC	k
k/λ sFLC ratio	k/λ	A ratio of the concentration of κ to λ sFLC (indicates monoclonality)	k/λ
dFLC	iFLC – uFLC	The difference in the concentration between the iFLC and uFLC	λ-k
Involved/ Uninvolved sFLC ratio	iFLC/uFLC	A ratio of the concentration of involved to uninvolved sFLC – could be κ/λ or λ/κ	λ/k

Normal adult serum	95 percentile range
k FLC	3.30 - 19.40 (mg/L)
λ FLC	5.71 - 26.30 (mg/L)
k/λ FLC ratio	0.26 - 1.65

An abnormal κ/λ FLC ratio is a highly sensitive indicator of monoclonal κ or λ FLC in serum. A study showed that patients with renal impairment had increased levels of FLC in serum and proposed an extended Freelite ratio reference range κ/λ FLC ratio: 0.37-3.1 for these patients.

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Uses of Freelite

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Freelite Assays

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