Freelite are sensitive and specific tests to measure kappa (κ) and lambda (λ) free light chains (FLCs). The assays are based on affinity purified polyclonal antibodies that are coated onto latex particles. These are used to produce turbidimetric kits; specific for κ FLCs and λ FLCs.
Antibody molecule showing the heavy and light chain structure, together with κ and λ FLCs
Freelite reacts only with exposed free light chain epitopes which are hidden when the light chain is bound to the heavy chain.
Freelite is recommended for use in patients with monoclonal gammopathies including: